Effect of M20 Interleukin-1 Inhibitor on Normal and Leukemic Human Myeloid Progenitors
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چکیده
This study aimed to assess the effect of the M20 interleukin-1 (IL-I) inhibitor on normal and leukemic hematopoietic cells. The M2O-derived IL-I inhibitor was found to inhibit the growth of various hematopoietic cells. The in vitro proliferation of myeloid cell lines in serum-containing medium or proliferation of these cells induced by IL-1 in serum-free medium (measured by 3H-TdR) were inhibited by the M20 IL-1 inhibitor. In addition, growth of normal progenitors and fresh leukemic cells stimulated by granulocyte-macrophage colonystimulating factor (GM-CSF) (as measured by colony and
منابع مشابه
Effect of M20 interleukin-1 inhibitor on normal and leukemic human myeloid progenitors.
This study aimed to assess the effect of the M20 interleukin-1 (IL-1) inhibitor on normal and leukemic hematopoietic cells. The M20-derived IL-1 inhibitor was found to inhibit the growth of various hematopoietic cells. The in vitro proliferation of myeloid cell lines in serum-containing medium or proliferation of these cells induced by IL-1 in serum-free medium (measured by 3H-TdR) were inhibit...
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